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Pediatric Heart Specialists was founded in 1983 by Penn Laird Sr. The original office was located at Northwest Highway and the Tollway. In 2001, Tracy Laird and Penn Laird II joined the practice, and the office moved to its current location at Medical City Hospital. In 2009, Dr. Amit Verma joined the practice, followed by Holly Tomlin as the practice's first nurse practitioner in 2011.  In early 2012, Dr. Michael Day joined the practice, followed by Dr. Christy Glasow and Dr. Shannon Blalock in 2013.  In 2015, the practice added Ashley Hanson as its second nurse practitioner and in 2016, Dr. Alan Sing joined on as well.

Over the years, the practice has gradually added locations and satellite offices throughout the north and east Texas regions. A second full-time office was opened in Plano in 2006. In the middle of 2010, the practice opened a second branch in the Houston area and has continued to expand throughout the South Texas region.